Table 2.
Tumor characteristics, type of surgery, adjuvant treatment and survival outcomes by mode of breast cancer detection
| |
MODE OF DETECTION |
|
|||
|---|---|---|---|---|---|
| |
SYMPTOMATIC |
SCREEN DETECTED |
P-VALUE |
||
| TUMOR CHARACTERISTICS | No. | % | No. | % | |
| TOTAL |
334 |
74.5 |
114 |
25.5 |
|
|
Tumor size |
|
|
|
|
<.0001 |
| T1 |
166 |
51.7 |
84 |
80.8 |
|
| T2 |
123 |
38.3 |
19 |
18.3 |
|
| T3–T4 |
32 |
10.0 |
1 |
1.0 |
|
|
No. of positive Lymph nodes |
|
|
|
|
.01 |
| All lymph nodes negative |
167 |
52.8 |
73 |
70.2 |
|
| 1–3 |
77 |
24.4 |
20 |
19.2 |
|
| 4–9 |
52 |
16.5 |
9 |
8.7 |
|
| ≥10 |
20 |
6.3 |
2 |
1.9 |
|
|
Histological grade |
|
|
|
|
<.0001 |
| 1 |
23 |
7.2 |
20 |
18.5 |
|
| 2 |
120 |
37.7 |
49 |
45.4 |
|
| 3 |
175 |
55.0 |
39 |
36.1 |
|
|
Immunoistochemical characteristics |
|
|
|
|
|
|
ER status |
|
|
|
|
.11 |
| Positive |
236 |
70.7 |
88 |
77.2 |
|
| Negative |
98 |
29.3 |
26 |
22.8 |
|
|
PR status |
|
|
|
|
.04 |
| Positive |
227 |
68.0 |
89 |
78.1 |
|
| Negative |
107 |
32.0 |
25 |
21.9 |
|
|
Ki-67 |
|
|
|
|
.02 |
| ≤20% |
141 |
44.1 |
60 |
57.1 |
|
| >20% |
179 |
55.9 |
45 |
42.9 |
|
|
HER2 status |
|
|
|
|
.96 |
| 0, 1+ |
227 |
70.1 |
76 |
70.4 |
|
| 2+ |
46 |
14.2 |
16 |
14.8 |
|
| 3+ |
51 |
15.7 |
16 |
14.8 |
|
|
Molecular Subtypes |
|
|
|
|
.04 |
| Luminal A |
193 |
59.0 |
74 |
68.5 |
.09 |
| Luminal B |
59 |
18.2 |
18 |
16.7 |
.71 |
| Non-Luminal HER2+ |
38 |
11.0 |
14 |
13.0 |
.79 |
| No Basal-like |
18 |
5.6 |
2 |
1.8 |
.01 |
| Basal-like |
16 |
4.9 |
0 |
|
|
|
TREATMENT CHARACTERISTICS |
|
|
|
|
|
|
Type of surgery |
|
|
|
|
.005 |
| Conservative |
242 |
74.7 |
88 |
88.0 |
|
| Mastectomy |
82 |
25.3 |
12 |
12.0 |
|
|
Adjuvant Therapy |
|
|
|
|
.04 |
| None |
36 |
11.8 |
15 |
13.6 |
|
| Radiation only |
64 |
21.1 |
37 |
33.6 |
|
| Chemotherapy only |
33 |
10.9 |
8 |
7.3 |
|
| Radiation and Chemotherapy |
171 |
56.2 |
50 |
45.5 |
|
|
Hormone given |
244 |
81.3 |
92 |
83.6 |
.23 |
|
OUTCOME CHARACTERISTICS |
|
|
|
|
|
|
Vital status |
|
|
|
|
<.0001 |
| Alive, no evidence of disease |
226 |
69.7 |
100 |
88.4 |
|
| Alive with this cancer |
40 |
12.3 |
5 |
4.4 |
|
| Dead, no evidence of disease |
4 |
1.2 |
0 |
- |
|
| Dead from this cancer |
54 |
16.6 |
8 |
7.0 |
|
| Recurrence type |
|
|
|
|
.001 |
| None |
230 |
71 |
100 |
88.5 |
|
| Loco-Regional |
18 |
5.6 |
3 |
2.7 |
|
| Distant | 76 | 23.5 | 10 | 8.8 | |
Abbreviations: BC, breast cancer; Subtypes: Luminal A (ER+ and/or PR+) and HER2-; Luminal B (ER+ and/or PR+) and HER2+; Non-Luminal HER2+ (ER- and PR-) and HER2+; Triple Negative (ER-, PR- and HER2-).
Abbreviations: BC, breast cancer.