Table 5.

Cox multivariate analysis of disease-free and overall survival by molecular subtypes

	Recur	P-value	Death	P-value
	HR (95% CI)		HR (95% CI)
Luminal A
Mode of BC Detection
Screen Detected	1.00		1.00
Symptomatic	2.73 (1.05–7.13)	.03	4.2 (0.97–18.16)	.05
Tumor size		.91		.72
T1	1.00		1.00
T2	1.11 (0.56–2.2)	.73	1.19 (0.51–2.78)	.74
T3–T4	1.09 (0.42–2.87)	.81	0.69 (0.18–2.58)	.52
No. of positive Lymph nodes		<.0001		<.0001
All lymph nodes negative	1.00		1.00
1–3	1.9 (0.81–4.47)	.12	2.84 (0.89–9.05)	.07
≥4	6.27 (3.05–12.91)	<.0001	9.69 (3.57–26.26)	<.0001
Luminal B
Mode of BC Detection
Screen Detected	1.00		1.00
Symptomatic	2.66 (0.59–11.88)	.21	2.79 (0.33–23.7)	.33
Tumor size		.4		.05
T1	1.00		1.00
T2	1.05 (0.39–2.77)	.91	0.56 (0.11–2.92)	.53
T3–T4	2.61 (0.58–11.71)	.22	5.59 (1.03–30.22)	.04
No. of positive Lymph nodes		.12		.74
All lymph nodes negative	1.00		1.00
1–3	2.55 (0.82–7.88)	.01	0.81 (0.14–4.52)	.81
≥4	3.55 (1.02–12.42)	.04	1.66 (0.35–7.75)	.52
Non Luminal Her2+
Mode of BC Detection
Screen Detected	1.00		1.00
Symptomatic	1.86 (0.19–18.18)	.72	1.43 (0.14–14.05)	.91
Tumor size		.03		.09
T1	1.00		1.00
T2	1.77 (0.47–6.67)	.44	5.48 (1.02–29.2)	.05
T3–T4	8.62 (1.65–44.78)	.01	8.56 (1.05–69.9)	.04
No. of positive Lymph nodes		.81		.42
All lymph nodes negative	1.00		1.00
1–3	1.47 (0.38–5.6)	.84	0.41 (0.09–1.88)	.22
≥4	1.54 (0.34–7.05)	.51	1.07 (0.22–5.1)	.91
Triple Negative
Mode of BC Detection
Screen Detected	1.00		1.00
Symptomatic	0.14 (0.008–2.39)	.11	n.e*.
Tumor size		.11		.12
T1	1.00		1.00
≥T2	7.17 (1.15–44.72)	.03	7.41 (0.61–89.8)	.14
No. of positive Lymph nodes		.001		.01
All lymph nodes negative	1.00		1.00
All lymph nodes positive	3.58 (3.65–7.76)	.001	4.85 (1.46–16.13)	.01

*n.e. not evaluable.