Table 2.

Within sib pair association statistics for seven SNPs with various lipid traits

Gene	Reference for test SNP	Effect Size from European GWAS	SNP (Minor allele frequency)	Phenotype associated with test SNP in previous GWAS	Triglyceride	Total Cholesterol	HDL-cholesterol	LDL-cholesterol
APOA5	[10]	16.88 mg/dl [10]	rs662799 (G=0.19)	Triglyceride	0.18 (0.11, 0.25, p=1.97 x 10-7)	0.08 (0.02, 0.14, p=0.01)	−0.04 (−0.10, 0.02, p=0.21)	0.05 (−0.01, 0.12, p=0.12)
APOB	[9]	4.89 mg/dl [9]	rs562338 (A=0.13)	LDL-Cholesterol	−0.006 (−0.09, 0.07, p=0.87)	−0.08 (−0.15, -0.002, p=0.04)	0.03 (−0.04, 0.10, p=0.44)	−0.09 (−0.17, -0.01, p=0.03)
CETP	[10]	4.12 mg/dl [10]	rs1864163 (A=0.20)	HDL-Cholesterol	−0.004 (−0.07, 0.07 , p=0.90)	−0.05 (−0.12, 0.01, p=0.12)	−0.01 (−0.08, 0.05, p=0.65)	−0.05 (−0.11, 0.02, p=0.18)
GCKR	[10]	8.59 mg/dl [10]	rs780094 (T=0.21)	Triglyceride	0.11 (0.05, 0.18, p=0.001)	0.11 (0.05, 0.17, p=3.9x10-4)	0.04 (−0.01, 0.10, p=0.15)	0.07 (0.004, 0.13, p=0.03)
LDLR	[4]	−6.99 mg/d [4]	rs6511720 (T=0.07)	LDL-Cholesterol	0.005 (−0.11, 0.012, p=0.93)	−0.06 (−0.17, 0.05, p=0.28)	0.04 (−0.06, 0.15, p=0.39)	−0.06 (−0.18, 0.04, p=0.24)
LIPC	[10]	1.38 mg/dl [10]	rs4775041 (C=0.21)	HDL-Cholesterol	0.03 (−0.04, 0.10, p=0.40)	0.006 (−0.05, 0.07, p=0.84)	0.08 (0.02, 0.14, p=0.007)	−0.03 (−0.09, 0.03, p=0.35)
LPL	[10]	2.09 mg/dl [10]	rs10503669 (A=0.12)	Triglyceride	−0.18 (−0.26, -0.09, p=1.0 x 10-4)	−0.09 (−0.17, 0.007, p=0.03)	0.03 (−0.05, 0.11, p=0.42)	−0.04 (−0.12, 0.04, p=0.36)

Data presented as β specific for z-scores with 95% CI and p-value.