Table 1.
Effect of kolaviron, a biflavonoid fraction from Garcinia kola seeds, on body weight and relative weight of organs in STZ-diabetic rats
| Treatment | Body weight (g) | Weight (g) | Relative weight (as % body weight) |
||||||
| Initial | Final | Change | Liver | Kidney | Heart | Liver | Kidney | Heart | |
| Normal | 225.1±5.3 | 241.3±6.2 | 16.2±5.6 | 6.8±0.5 | 1.3±0.1 | 0.8±0.1 | 2.8±0.3 | 0.5±0.09 | 0.3±0.05 |
| TZ only | 226.3±4.7 | 178.0±9.1* | −48.3±8.3* | 7.1±0.8 | 1.2±0.2 | 0.8±0.1 | 4.0±0.3* | 0.6±0.07 | 0.4±0.05 |
| STZ+KV | 223.4±5.5 | 215.2±4.1** | −8.2±2.4** | 6.9±0.4 | 1.3±0.2 | 0.8±0.2 | 3.2±0.2** | 0.6±0.10 | 0.4±0.03 |
| STZ+GB | 228.4±4.4 | 204.6±8.0** | −23.8±7.3* | 7.2±0.8 | 1.3±0.2 | 0.8±0.1 | 3.5±0.4** | 0.6±0.08 | 0.4±0.08 |
Values are means ± S.D. of 6 rats per group
*
Significantly different from normal at p< 0.05 STZ= Streptozotocin, KV= Kolaviron at 100 mg/kg
**
Significantly different from STZ only at p< 0.05 GB= Glibenclamide