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. 2011 Jul 30;33(24):3114–3123. doi: 10.1093/eurheartj/ehr245

Figure 2.

Figure 2

Interleukin-7 in aortas is down-regulated with cholesterol lowering in Apoe−/− mice. (A) Pathways influenced by cholesterol lowering. Microarray analysis was performed on RNA isolated from aortas harvested 10 days after helper-dependent adenoviral vector injection. Pathway Express and Ontology Express were used for functional profiling. ↓, down-regulation; ↑, up-regulation. Parenthesis: novel impact factor, number of genes affected/number of genes in each pathway. (B) Relative mRNA expression. *P< 0.05. n = 5. (C) Representative interleukin-7 immunoreactivity in cross-sections of aorta 41 weeks after treatment. Bar, 50 µm. (D) Interleukin-7 immunoreactive areas in the lesions. *P< 0.01 (vs. baseline and helper-dependent adenoviral vector-0 group; n = 4/group.