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. 2011 Jul 30;33(24):3114–3123. doi: 10.1093/eurheartj/ehr245

Figure 7.

Figure 7

Interleukin-7 deficiency attenuates migration of monocyte/macrophages to atherosclerotic lesions. (A) Plasma cholesterol levels; n = 6/group. (B) Blood cell counts in recipient mice; n = 6/group. Abbreviations are listed in Figure 6B legend. (C) Plasma monocyte chemoattractant protein-1 levels; n = 6/group. (D) Atherosclerotic lesion size on cross-sections. *P< 0.0001 (vs. baseline, one-way ANOVA on Ranks); n = 8 (baseline), 6 (bone marrow transplantation-Il7+/+), and 6 (bone marrow transplantation-Il7−/−). Median, 25 and 75th percentiles are shown. (E) Lack of IL-7 in BM-derived cells attenuates macrophage migration to the atherosclerotic lesions. *P< 0.05; n = 6/group. (F) α-Actin positive area. *P= 0.001; n = 6/group. ×400. Bar, 20 μm.