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. 2013 Feb 14;6:9. doi: 10.1186/1756-6606-6-9

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Copyright ©2013 Paquet et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of disrupting mGluR5/Homer interactions on OGD-induced astrocytic cell death. A) Representative immunoblot of Homer1b co-immunoprecipitation with Flag mGluR5a from HEK 293 cells transfected with plasmid cDNAs encoding Homer 1b (1 μg) and Flag-mGluR5a (3 μg) and treated with and without Homer (35 μM) and scrambled (35 μM) Tat-tagged peptides for 1 h. B) Quantification of apoptotic CD1 astrocytic cell death following 12 OGD and 24 h re-oxygenation following the treatment of the astrocytic cultures during the OGD period with Homer and scramble tat-tagged peptides (35 μM). Data represents the mean ± SD of 6 independent experiments. Asterisks represent significant differences by students t test, p<0.05.