Table 3.

BIM neuropsychological assessment

Domain	Test	Description
Attention	Attention Network Test [51-53]	Computerized test of the efficiency of 3 attention networks, including tests of altering, orienting and executive control (flanker test)
	Auditory Consonant Trigram Test [54]	Auditory presentation of 3 consonant trigrams (i.e., three single consonant letters) followed by a number. The subject is instructed to subtract from that number for several seconds until cued, and then asked to recall the letters
Processing Speed	Symbol-Digit Modalities [55]	Simple substitution task pairing specific numbers with given geometric figures. Both written (90 seconds) and oral (90 seconds) forms administered
Verbal Memory	Buschke Selective Reminding Test [56,57]	1. Memory Test (List learning of 12 words rehearsed for six trials)
		2. Cued Recall
		3. Multiple Choice recognition
		4. Oral delayed recall of 12 words (30 minutes following multiple choice)
Visual Memory	Medical College of Georgia Complex Figures Test (MCG) [58]	A test of visual memory in which the subject is asked to copy the figure and then draws it from memory at an immediate test and at a 30 minute delay
Executive Function	Delis-Kaplan Executive Function System (D-KEFS) [59]	1. Card Sorting Test- one card set is randomly assigned to each session (i.e., one card set per phase) in which the free-sorting and recognition conditions are tested
		2. Color-word Interference Test- four conditions are presented to participants (i.e., colour naming, word reading, inhibition, and inhibition/switching) and participants must follow the presented rule to orally complete the task as accurately as possible
		3. Verbal Fluency Test- participants must say as many words as possible in 60 seconds for each condition (i.e., letter fluency, category fluency, and category switching)
Premorbid Intellectual Ability	North American Adult Reading Test [60]	61 different rare words are presented with scoring based on American and Canadian punctuation rules
Mood	Profile of Mood States [46,61]	65 adjectives are presented that are rated by subjects using a 5-point scale. From the responses 6 factors are derived (tension-anxiety, vigour-activity, depression-dejection, fatigue-inertia, anger-hostility, and confusion-bewilderment
Sleep	Pittsburg Sleep Quality Index [47]	Self-report questionnaire of the last month sleep habits/sleep quality
	Epworth Sleepiness Scale [48]	Self-report of general daytime sleepiness
Social Support	Modified version of the Lubben Social Network Scale [50]	Self-report questionnaire of perceived social support from family, friends, and other study participants
Cognitive Activity	Lifetime Cognitive Questionnaire (Test 1A only) [62]	20 questions that assess cognitive activities participants were engaged in during childhood (age 6), teens (age 12), young adults (age 18), and adulthood (age 40)
	Current Cognitive Questionnaire (all test sessions) [62]	23 questions that assess the degree to which participants are cognitively active in their lives at the present time