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. 2013 Feb 22;18(1):4. doi: 10.1186/2047-783X-18-4

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Copyright ©2013 Zhuo et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A case with chronic tubular interstitial nephritis (TIN) and diabetic nephropathy (DN). (A) Deposits of mainly IgG collected in the basement membrane and appeared in a linear pattern as viewed by immunofluorescence (IF, 200×). (B) (PAS, 100×) and (C) (Masson, 100×) show severe mesangial expansion (Kimmelstiel-Wilson nodules) and severe tubular injury with only minimal cell infiltration in the interstitial area. DN, diabetic nephropathy; IF, immunofluorescence; IgG, immunoglobulin G; PAS, periodic acid-Schiff; TIN, tubular interstitial nephritis.