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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: J Immunol. 2008 Aug 15;181(4):2620–2625. doi: 10.4049/jimmunol.181.4.2620

Figure 6. The resolution of Rag DSBs in NHEJ-sufficient or NHEJ-deficient cells in the presence or absence of Atm signaling.

Figure 6

The schematic shows the products generated after initiation of an inversional rearrangement in each genetic background used in this study. In NHEJ-sufficient cells, Atm signaling is required to prevent formation of hybrid joints and accumulation of un-repaired DNA ends. Lack of Atm signaling in NHEJ-deficient cells, however, does not lead to an increase in the formation of hybrid joints. Triangles represent recombination signals (RSs); rectangles represent coding segments. Size of arrows denotes relative frequency of formation of each product; dotted line indicates that the outcome is near the limit of detection. INV: normal coding and signal joints; CE: coding end; HJ: hybrid joint.