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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Life Sci. 2013 Jan 24;92(6-7):337–344. doi: 10.1016/j.lfs.2012.12.013

Figure 3.

Figure 3

Effects of nicotine and nicotine plus varenicline on mIPSCs in hippocampal CA1 pyramidal neurons. A. Representative traces from a CA1 pyramidal neuron featuring nicotine’s increase in GABA release and varenicline’s subsequent reduction in GABA release measured as mIPSC frequency. B. Cumulative probability plots of nicotine and varenicline’s effects on GABAAR mIPSC IEI from CA1 pyramidal neurons (n = 10 cells; number of events over 3 min: baseline = 3069, nicotine = 4430, nicotine + varenicline = 3584). C. Cumulative probability plots of nicotine and varenicline’s effects on GABAAR mIPSC amplitude from CA1 pyramidal neurons. D. Histograms and Gaussian curves of mIPSC amplitudes (10 pA bins). Color code: baseline (blue), nicotine (black), nicotine plus varenicline (red).