Table 1.
Drug-induced changes in mean GABAAR mIPSC inter-event interval
The population mean ± SEM values of GABAAR mIPSC IEI are expressed as % of baseline (100%) after the addition of the drug(s). The percent of baseline in response to drug application was calculated for each individual neuron, and averaged for the number of cells recorded from (n).
| Drugs applied to slices (10 μM) | CA1 Pyramidal neurons | # of cells (n) | MS/DB neurons | # of cells (n) |
|---|---|---|---|---|
| Mean IEI (% of baseline) | Mean IEI (% of baseline) | |||
| Varenicline | 76.2 ± 4.8%* Decreased: 5/6 (75.5%) |
6 | 128.1 ± 21.0% Decreased: 6/13 (70.3%) Increased: 5/13 (205.4%) |
13 |
| Varenicline + Nicotine | 69.7 ± 7.7%* Decreased: 5/6 (62.2%) |
6 | 107.4 ± 22.0% Decreased: 6/11 (64.0%) Increased: 3/11 (195.3%) |
11 |
| Nicotine | 80.4 ± 7.4%* Decreased: 6/10 (69.2%) |
10 | 74.8 ± 13.3% Decreased: 6/9 (52.8%) |
9 |
| Nicotine + Varenicline | 84.3 ± 7.0%* Decreased: 6/10 (73.0%) |
10 | 88.4 ± 11.8% Decreased: 3/9 (49.2) Increased: 3/9 (117.5%) |
9 |
*
indicates significance (p>0.05, Student’s t-test). The number of cells responding with a decrease in IEI (increased frequency) or an increase in IEI (decrease in frequency) and their % of baseline values are listed underneath the mean population change. A change of less than ±10% from baseline was considered as no change.