Table I.
Simulation study based on 100 replicates. Correlation structures include auto (auto-regressive), band (banded) and comp (compound symmetry). P: number of covariates identified; TP: number of true positives.
| Meta-analysis | Intensity approach | Integrative analysis | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Enet | Boost | SBoost | Enet | Boost | SBoost | Enet | iBoost | iSBoost | ||||||||||||
| #cov | corr | ρ | P | TP | P | TP | P | TP | P | TP | P | TP | P | TP | P | TP | P | TP | P | TP |
| 1000 | auto | 0.3 | 152 | 20 | 151 | 20 | 118 | 18 | 93 | 20 | 95 | 20 | 30 | 20 | 85 | 20 | 138 | 20 | 20 | 20 |
| 0.7 | 127 | 20 | 210 | 20 | 83 | 19 | 77 | 20 | 80 | 20 | 28 | 20 | 37 | 20 | 137 | 20 | 21 | 20 | ||
| band | 0.2 | 103 | 19 | 209 | 20 | 72 | 18 | 80 | 20 | 76 | 20 | 26 | 20 | 33 | 20 | 138 | 20 | 22 | 20 | |
| 0.33 | 136 | 20 | 191 | 20 | 90 | 18 | 72 | 19 | 91 | 20 | 29 | 20 | 56 | 20 | 142 | 20 | 22 | 20 | ||
| comp | 0.3 | 123 | 18 | 193 | 20 | 90 | 16 | 79 | 20 | 122 | 20 | 36 | 20 | 102 | 20 | 159 | 20 | 40 | 19 | |
| 0.7 | 98 | 20 | 212 | 20 | 48 | 12 | 82 | 20 | 106 | 19 | 30 | 13 | 48 | 20 | 133 | 20 | 37 | 17 | ||
| 2000 | auto | 0.3 | 205 | 20 | 143 | 18 | 173 | 16 | 91 | 20 | 115 | 20 | 43 | 20 | 117 | 20 | 176 | 20 | 21 | 20 |
| 0.7 | 224 | 19 | 196 | 20 | 144 | 18 | 78 | 20 | 96 | 20 | 36 | 20 | 104 | 20 | 168 | 20 | 21 | 20 | ||
| band | 0.2 | 208 | 17 | 231 | 20 | 129 | 17 | 67 | 20 | 89 | 20 | 32 | 20 | 118 | 20 | 166 | 20 | 22 | 20 | |
| 0.33 | 199 | 20 | 178 | 20 | 150 | 16 | 84 | 18 | 94 | 20 | 37 | 20 | 120 | 20 | 173 | 20 | 22 | 20 | ||
| comp | 0.3 | 190 | 19 | 185 | 17 | 150 | 14 | 68 | 20 | 149 | 20 | 43 | 18 | 112 | 20 | 199 | 20 | 41 | 18 | |
| 0.7 | 211 | 20 | 258 | 19 | 79 | 11 | 101 | 20 | 134 | 18 | 36 | 12 | 94 | 20 | 172 | 19 | 42 | 16 | ||