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The effect of oxygen saturation on PVR in lambs with PPHN induced by antenatal ductal ligation: Median (solid line) and 25th and 75th percentile lines (dashed lines) are shown in the figure. Saturation range of 90% to 97% is associated with low PVR. (From Lakshminrusimha S, Swartz DD, Gugino SF, et al. Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension. Pediatr Res 2009;66(5):542; with permission.)
