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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Clin Perinatol. 2012 Sep;39(3):655–683. doi: 10.1016/j.clp.2012.06.006

Fig. 7.

Fig. 7

The effect of OI at initiation of iNO on the incidence of ECMO and death in various trials: the size of the bubble is based on the number of infants enrolled in the iNO arm in that trial. The OI at initiation corresponds approximately with the incidence of ECMO or death. A case series from Columbia-Presbyterian Hospital using gentle ventilation is associated with lower incidence of ECMO/death despite high OI at initiation of iNO,126 suggesting that prior exposure to oxygen is a more important factor than precise OI at initiation of iNO.