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. 2013 Mar 15;8(3):e59073. doi: 10.1371/journal.pone.0059073

Figure 12. IL-6 expression in immDCs on silencing SOCS-1 and SOCS-3.

Figure 12

ELISA analysis reavealed the diminishing of IL-6 expression on subjecting immDCs, incubated with Nef and gp120, to SOCS-1 knock down. However, silencing SOCS-3 caused an increase in the expression of IL-6 in a dose dependent manner. The X-axis denotes the dosage of SOCS-1 siRNA and SOCS-3 siRNA in nM/ml. The Y-axis denotes the concentration of IL-6 in pg/ml. Data represent the mean±SEM (n = 3). Statistical analysis was performed using Student's t-test, with the levels of significance defined as p*<0.05.