Table 6.
Sensitivity of the MDASI-MM to impact of therapy: comparison of subscale and individual symptom scores pre-HSCT and 7 days post-HSCT (n= 66)
| |
Pre-HSCT |
Post-HSCT |
Differencea |
Effect size |
||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | |||
| MDASI-MM subscales |
|
|
|
|
|
|
| Core |
1.60 |
1.30 |
3.57 |
1.76 |
1.97b |
1.29 |
| Severity |
1.43 |
1.14 |
3.21 |
1.62 |
1.78b |
1.33 |
| Interference |
2.32 |
2.29 |
4.51 |
2.62 |
2.19b |
0.95 |
| Individual items |
|
|
|
|
|
|
| Lack of appetite |
0.96 |
1.77 |
5.73 |
3.14 |
4.77b |
1.43 |
| Diarrhea |
0.56 |
1.25 |
5.37 |
3.39 |
4.81b |
1.36 |
| Nausea |
0.36 |
0.96 |
4.38 |
3.28 |
4.02b |
1.20 |
| Dry mouth |
1.22 |
2.14 |
4.94 |
3.35 |
3.72b |
1.11 |
| Fatigue |
2.99 |
2.52 |
5.86 |
2.40 |
2.87b |
1.07 |
| Drowsiness |
1.88 |
2.12 |
4.53 |
2.56 |
2.65b |
0.88 |
| Mouth/throat sores |
0.34 |
0.99 |
2.82 |
3.29 |
2.48b |
0.81 |
| Vomiting |
0.06 |
0.29 |
2.29 |
3.16 |
2.23b |
0.70 |
| Muscle weakness |
1.92 |
2.10 |
3.45 |
2.37 |
1.53b |
0.56 |
| Disturbed sleep |
2.47 |
2.61 |
4.03 |
2.79 |
1.56b |
0.49 |
| Distress |
1.82 |
2.41 |
3.03 |
2.91 |
1.21b |
0.48 |
| Pain |
2.84 |
2.80 |
4.11 |
2.98 |
1.27c |
0.44 |
| Sadness |
1.37 |
2.34 |
2.05 |
2.92 |
0.68c |
0.30 |
| Difficulty paying attention |
1.06 |
1.57 |
1.57 |
2.01 |
0.51c |
0.29 |
| Shortness of breath |
0.81 |
1.54 |
1.39 |
2.12 |
0.58c |
0.25 |
| Rash |
0.38 |
1.33 |
0.88 |
2.00 |
0.50 |
0.21 |
| Constipation |
0.95 |
1.67 |
0.65 |
1.96 |
−0.30 |
0.20 |
| Difficulty remembering |
1.21 |
1.90 |
1.44 |
1.83 |
0.23 |
0.15 |
| Numbness |
2.90 |
3.00 |
2.70 |
2.99 |
−0.20 |
0.09 |
| Bone aches | 2.31 | 2.38 | 2.48 | 2.76 | 0.17 | 0.03 |
a Positive values indicate mean increase in symptoms post-HSCT; negative indicate mean symptom improvement.
b Significant at P < .001.
c Significant at P < .05.