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. 2013 Mar 15;8(3):e59182. doi: 10.1371/journal.pone.0059182

Figure 7. Thymic Treg numbers were maintained in NOD mice on days 14 and 21 after infection.

Figure 7

Absolute numbers of thymic Treg (CD3+CD4+CD25+Foxp3+) and Teff (CD3+CD4+Foxp3−) cells in NOD (A) and C57BL/6 (B) mice on days 14 and 21 post infection. Each data point indicates results from a pool of cells from 2 to 4 mice, normalized to represent cells obtained from a single mouse. C, Decreases in total CD4+ T cell (CD3+CD4+) numbers, and in the Treg subset (CD3+CD4+CD25+Foxp3+) in the spleen (C) and PLN (D) of RRV-infected NOD and C57BL/6 mice compared with controls at days 14 (C) and 21 (D) post infection. Each data point represents a pool of cells from 4 to 5 mice, normalized to represent cells/mouse. Greater numbers of PLN cell pools than thymocyte and splenocyte pools were analysed from C57BL/6 mice, due to PLN availability from other studies. Bar = mean. * p = 0.02; ** p = 0.008; tr  =  trend, 0.05≤p≤0.06.