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. 2013 Mar 15;8(3):e59083. doi: 10.1371/journal.pone.0059083

Figure 1. FGF2 suppresses E-cadherin mRNA and protein levels in OVCAR-4 and SKOV-3 cells.

Figure 1

(A) OVCAR-4 and SKOV-3 cells were treated with 10 ng/ml FGF2 for 0 to 24 h as indicated, and then E-cadherin mRNA levels were analyzed by RT-qPCR. (B and C) OVCAR-4 and SKOV-3 cells were treated with different doses of FGF2 for 24 h after which E-cadherin mRNA levels (B) and protein levels (C) were analyzed by RT-qPCR and Western blotting, respectively. Results represent the mean ± SEM (n = 3; values without a common letter are significantly different, P<0.05). Data were analyzed by one-way ANOVA followed by Tukey's multiple comparison test.