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. 2013 Mar 15;8(3):e59599. doi: 10.1371/journal.pone.0059599

Figure 1. iNKT cells reduce the sensitivity of BALB/c mice to IAV infection.

Figure 1

Jα18−/− mice and BALB/c mice (n = 10) were intranasally infected with a lethal dose (3000 PFU) of IAV. (A) Increased frequency of iNKT cells after IAV infection. Representative FACS plots of iNKT cell frequencies in the lung of BALB/c mice stained with CD1d: PBS57 loaded tetramer and TCR-β antibody, gated on viable lymphocytes with percentage of cells in the iNKT cell gate indicated next to the gate. (B) Total iNKT cell numbers in the lung were determined by flow cytometry at different days post infection (DPI). Data is presented as mean ± standard error of the mean (SEM), n = 3. * P>0.05 (C) The weight loss of Jα18−/− mice and BALB/c mice has been monitored daily after IAV infection. Jα18−/− mice show augmented weight loss compared to wild type mice. Data are representative of three independent experiments.