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. 2013 Mar 15;8(3):e59302. doi: 10.1371/journal.pone.0059302

Figure 2. T-cell activation and exhaustion and its correlations with HCV-RNA in HIV/HCV-coinfection and control groups.

Figure 2

A: percentages of HLA-DR+CD38+ activated CD4+ (left) and CD8+ T-cells (right). B: percentages of PD-1 positive CD4+ and CD8+ T-cells. C: percentages of Tim3-positive CD4+ and CD8+ T-cells. D: percentage of death receptor Fas positive CD4+ and CD8+ T cells. E-H: correlations of HCV viral load within HIV-HCV coinfected (open dots) and HCV monoinfected patients (closed dots) with percentages of HLA-DR and CD38 positive CD8 T cells (E); PD-1 positive CD8 T cells (F); Tim-3 positive CD8 T cells (G) and Fas positive CD8 T cells (H). HCV viral loads are depicted in IU/mL. P-values are indicated with * (p<0.05), ** (p<0.01) or *** (p<0.0001). Spearman r and p-value of correlations are depicted in the upper left corner of each graph; red lines represent semilog fit lines.