Table 2. Correlations of clinical parameters and T cell markers.

	CD4			CD8
	Spearman R		p-value	Spearman R		p-value
HCV-RNA
HLA-DR+CD38+	0.28		0.08	0.37		0.03
PD1+	0.52		<0.01	0.55		0.03
Tim3+	0.01		n.s.	0.17		n.s.
Fas+	0.20		n.s.	0.32		0.05
ALT
HLA-DR+CD38+	-0.09		n.s.	0.13		n.s.
PD1+	0.16		n.s.	0.26		n.s.
Tim3+	-0.17		n.s.	0.24		n.s.
Fas+	0.24		n.s.	0.12		n.s.
Liver fibrosis	F0–F2	F3–F4	P-value	F0–F2	F3–F4	p-value
HLA-DR+CD38+	1.6%	1.9%	n.s.	4.4%	5.4%	n.s.
PD1+	10.2%	10.4%	n.s.	14.6%	9.8%	n.s.
Tim3+	0.6%	1.1%	n.s.	0.8%	0.7%	n.s.
Fas+	57%	66%	n.s.	34%	32%	n.s.

Spearman correlations of HCV-RNA and ALT with expression of activation and exhaustion markers and median expression of these markers in patients with F0–F2 versus F3–F4 fibrosis in all HCV-monoinfected and HIV/HCV-coinfected patients.