Table 2.
Risk factors for IHD and CVA by Cox multivariate models in each age group (IHD, upper; CVA, lower)
|
n = 4014 |
Total (n = 4014) |
<65 years (n = 1267) |
65-74 years (n = 1731) |
≥75 years (n = 1016) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IHD | Adjusted HR | 95% CI | P | Adjusted HR | 95% CI | P | Adjusted HR | 95% CI | P | Adjusted HR | 95% CI | P |
|
Gender (women vs. men) |
1.103 |
0.972–1.268 |
0.197 |
1.044 |
0.967–1.073 |
0.456 |
1.085 |
0.978–1.210 |
0.101 |
1.132 |
0.992–1.278 |
0.019* |
|
Age (per 10 years) |
1.013 |
0.972–1.066 |
0.328 |
1.022 |
0.977–1.079 |
0.229 |
1.054 |
1.002–1.106 |
0.049* |
1.005 |
0.871–1.139 |
0.682 |
|
Duration of Diabetes (months) |
0.995 |
0.988–1.003 |
0.053 |
1.001 |
0.991–1.008 |
0.582 |
0.993 |
0.985–0.999 |
0.033* |
0.992 |
0.982–0.999 |
0.023* |
|
HbA1C (per 1%) |
1.171 |
1.001–1.356 |
0.047* |
1.327 |
1.025–1.686 |
0.032* |
1.219 |
0.973–1.487 |
0.083 |
0.792 |
0.479–1.059 |
0.134 |
| FPG (per 10 mg/dl) |
1.004 |
0.997–1.008 |
0.432 |
1.005 |
0.996–1.013 |
0.355 |
1.004 |
0.997–1.009 |
0.592 |
0.999 |
0.987–1.007 |
0.761 |
|
SBP(per 10 mmHg) |
1.008 |
0.995–1.021 |
0.186 |
1.030 |
1.000–1.055 |
0.035* |
1.014 |
0.994–1.037 |
0.175 |
0.986 |
0.954–1.014 |
0.331 |
| DBP(per 10 mmHg) |
0.995 |
0.978–1.015 |
0.618 |
0.982 |
0.948–1.024 |
0.386 |
0.980 |
0.950–1.011 |
0.206 |
1.027 |
0.986–1.073 |
0.202 |
| TG (quartile) |
1.005 |
0.889–1.166 |
0.555 |
1.002 |
0.996–1.006 |
0.502 |
1.108 |
0.997–1.220 |
0.065 |
1.001 |
0.961–1.046 |
0.454 |
|
LDL-C (quartile) |
1.318 |
1.103–1.585 |
0.023* |
1.571 |
1.128–2.524 |
0.016* |
1.050 |
0.932–1.176 |
0.112 |
1.156 |
0.998–1.309 |
0.054 |
|
HDL-C (quartile) |
0.751 |
0.611–0.917 |
0.005** |
0.828 |
0.646–1.017 |
0.072 |
0.987 |
0.966–1.008 |
0.204 |
0.629 |
0.401–0.856 |
0.001** |
| Non-HDL-C (quartile) |
1.023 |
0.981–1.072 |
0.075 |
1.025 |
1.001–1.121 |
0.044* |
1.073 |
0.982–1.161 |
0.086 |
0.941 |
0.791–1.102 |
0.621 |
|
LDL-C/HDL-C (quartile) |
1.583 |
1.298–1.945 |
0.001** |
2.324 |
1.516–3.795 |
0.001** |
1.359 |
1.028–1.824 |
0.021* |
1.407 |
1.015–2.592 |
0.029* |
|
CVA |
Adjusted HR |
95% CI |
P |
Adjusted HR |
95% CI |
P |
Adjusted HR |
95% CI |
P |
Adjusted HR |
95% CI |
P |
| Gender |
1.164 |
0.985–1.296 |
0.351 |
1.014 |
0.897–1.240 |
0.655 |
1.208 |
0.896–1.526 |
0.112 |
0.953 |
0.912–1.012 |
0.063 |
|
Age |
1.015 |
0.986–1.039 |
0.282 |
1.002 |
0.957–1.076 |
0.754 |
1.007 |
0.916–1.166 |
0.537 |
1.103 |
1.002–1.217 |
0.048* |
| Duration of Diabetes |
0.998 |
0.992–1.001 |
0.206 |
1.003 |
0.987–1.017 |
0.709 |
0.996 |
0.989–1.001 |
0.096 |
0.999 |
0.991–1.005 |
0.818 |
| HbA1C |
1.001 |
0.790–1.214 |
0.128 |
1.019 |
0.691–1.401 |
0.814 |
0.997 |
0.855–1.222 |
0.569 |
0.928 |
0.822–1.010 |
0.059 |
| FPG |
1.005 |
0.995–1.005 |
0.803 |
1.003 |
0.990–1.018 |
0.741 |
1.002 |
0.995–1.008 |
0.592 |
0.998 |
0.986–1.008 |
0.711 |
| SBP |
1.009 |
0.993–1.024 |
0.276 |
1.024 |
0.988–1.055 |
0.185 |
1.015 |
0.992–1.037 |
0.206 |
0.989 |
0.957–1.018 |
0.458 |
| DBP |
0.998 |
0.978–1.020 |
0.846 |
0.995 |
0.958–1.046 |
0.831 |
0.981 |
0.948–1.016 |
0.278 |
1.024 |
0.978–1.074 |
0.317 |
| TG |
1.132 |
0.908–1.302 |
0.156 |
1.053 |
0.658–1.742 |
0.833 |
1.253 |
0.900–1.780 |
0.184 |
1.169 |
0.746–1.853 |
0.497 |
|
LDL-C |
1.009 |
0.912–1.191 |
0.675 |
1.005 |
1.001–1.100 |
0.047* |
1.015 |
0.892–1.136 |
0.714 |
0.997 |
0.982–1.012 |
0.631 |
|
HDL-C |
0.742 |
0.596–0.901 |
0.003** |
0.715 |
0.591–1.191 |
0.200 |
0.750 |
0.494–1.000 |
0.049* |
0.536 |
0.320–0.851 |
0.007** |
|
Non-HDL-C |
0.981 |
0.945–1.019 |
0.206 |
1.021 |
1.003–1.141 |
0.045* |
0.942 |
0.872–1.013 |
0.172 |
1.012 |
0.954–1.077 |
0.226 |
| LDL-C/HDL-C | 1.180 | 0.951–1.477 | 0.132 | 1.271 | 0.819–2.232 | 0.263 | 1.114 | 0.853–1.582 | 0.356 | 1.209 | 0.803–1.847 | 0.364 |
The top panels show the analyses of IHD for subjects aged <65 years (left), 65–74 years (middle) and ≥75 years (right). The lower panels show the incidence of CVA. Bold indicate statistically significant factors. Hazard ratios and 95% CIs are shown. The ratio of males to females was 1. As LDL-C/HDL-C interacts strongly with LDL-C and HDL-C, and non-HDL-C interacts triglyceride and LDL-C, analysis of non-HDL-C and LDL-C/HDL-C were separately shown in methods section.