Table 2.
Numbers and infarct size
| |
|
Wild type |
Ob/ob |
DKO |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Condition | Sham | NP | P | Sham | NP | P | Sham | NP | P | |
|
N experiments (survivors) |
Untreated |
8 (8) |
11 (9) |
9 (9) |
6 (6) |
9 (6) |
8 (7) |
7 (6) |
7 (6) |
8 (7) |
| Diet |
|
|
|
7 (6) |
9 (6) |
8 (7) |
7 (6) |
7 (7) |
8 (8) |
|
| ACE-I |
6 (6) |
7 (6) |
8 (8) |
7 (7) |
9 (7) |
8 (7) |
7 (7) |
9 (7) |
8 (7) |
|
|
Weight (g) |
Untreated |
28.3±4.6 |
62.4±3.8 a |
59.1±9.5 a |
||||||
| Diet |
|
38.3±4.7 b |
37.9±3.4 b |
|||||||
| ACE-I |
27.1±3.4 |
62.9±9.4 ae |
63.6±8.5 ae |
|||||||
|
Area at risk (% of heart) |
Untreated |
0 |
15.4±7.6 c |
16.6±6.9 c |
0 |
15.6±6.1c |
12.4±5.5 c |
0 |
18.8±7.6 c |
12.9±3.5 c |
| Diet |
|
|
|
0 |
18.7±2.6 c |
19.4±6.6 c |
0 |
17.5±8.7 c |
17.9±10.7 c |
|
| ACE-I |
0 |
19.0±5.8 c |
18.8±7.4 c |
0 |
16.4±3.0 c |
17.5±8.8 c |
0 |
14.4±5.3 c |
16.1±7.1 c |
|
| Infarct size (% of area at risk) | Untreated |
0 |
50.2±6.5 c |
28.9±12.3 cd |
0 |
72.7±8.0 ac |
62.9±7.8 ac |
0 |
67.4±6.6 ac |
65.1±7.1 ac |
| Diet |
|
|
|
0 |
66.8±9.7 c |
56.5±6.4 cd |
0 |
71.2±12.3 c |
57.7±7.6 cd |
|
| ACE-I | 0 | 53.2±3.5 c | 23.6±6.1 cd | 0 | 69.6±8.6 ac | 49.7±5.5 abcde | 0 | 66.4±7.8 ac | 53.3±10.4 abcd | |
ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); NP: ischemia/reperfusion and Non-Preconditioned; P: ischemia/reperfusion and Preconditioned. “a” p<0.05 versus WT same treatment, same condition (sham; non-preconditioned; preconditioned); “b” p<0.05 versus same untreated genotype, same condition; “c” p<0.05 versus sham, same genotype, same treatment; “d” p<0.05 versus non-preconditioned, same genotype, same treatment; “e” p<0.05 versus diet, same genotype, same condition.