Table 1.
Characteristics of study subjects
| Disease classification | No asthma | Intermittent | Mild persistent | Moderate/severe persistent | p value |
|---|---|---|---|---|---|
| Number of subjects |
93 |
31 |
15 |
20 |
|
| Age(years) (±SD) |
7.6 ± 0.8 |
7.6 ± 0.5 |
7.4 ± 0.8 |
7.4 ± 1.0 |
0.54 |
| |
|
|
|
|
|
| Female |
46 (49%) |
10 (32%) |
6 (40%) |
8 (40%) |
0.38 |
| Male |
47 (51%) |
21 (68%) |
9 (60%) |
12 (60%) |
|
| Caucasian |
89 (96%) |
29 (94%) |
11 (73%) |
16 (80) |
0.008 |
| African American |
3 (3%) |
3 (10%) |
6 (40%) |
6 (30%) |
<0.0001 |
| American Indian |
4 (4%) |
0 (0%) |
0 (0%) |
0 (0%) |
0.84 |
| Asian |
0 (0%) |
1 (3%) |
0 (0%) |
0 (0%) |
0.42 |
| Hispanic or Latino |
4 (4 %) |
1 (3%) |
1 (7%) |
0 (0%) |
0.83 |
| Spirometry(median [25th, 75th]) |
|
|
|
|
|
| FEV1 |
1.50 [1.37, 1.72] |
1.54 [1.27, 1.66] |
1.23 [1.09, 1.63] |
1.46 [1.29, 1.83] |
0.11 |
| FEV1% pred |
103 [95, 109] |
103 [89, 113] |
90 [85, 101] |
102 [94, 107] |
0.43 |
| FVC |
1.85 [1.64, 2.06] |
1.81 [1.60, 2.05] |
1.62 [1.31, 1.93] |
1.88 [1.51, 2.21] |
0.06 |
| FVC% pred |
108 [100, 115] |
110 [98, 118] |
96 [94, 116] |
114 [105, 120] |
0.19 |
| FEV0.5 |
1.11 [1.01, 1.30] |
1.14 [0.97, 1.29] |
0.92 [0.78, 1.18] |
1.07 [0.97, 1.21] |
0.07 |
| FEF25-75 |
1.63 [1.23, 1.95] |
1.54 [1.03, 1.88] |
1.21 [0.98, 1.51] |
1.48 [1.25, 1.70] |
0.16 |
| PEF |
2.98 [2.58, 3.50] |
3.20 [2.59, 3.65] |
2.46 [2.16, 2.99] |
2.66 [2.51, 3.17] |
0.07 |
| FEV1/FVC |
0.85 [0.79, 0.88] |
0.82 [0.77, 0.86] |
0.82 [0.81, 0.88] |
0.81 [0.77, 0.86] |
0.43 |
| FEV0.5/FVC |
0.63 [0.58, 0.69] |
0.60 [0.55, 0.65] |
0.62 [0.56, 0.65] |
0.57 [0.55, 0.65] |
0.24 |
| Total lgE (median [25th, 75th]) |
38 [19, 92] |
49 [15, 103] |
149 [20, 331] |
218 [103, 475] |
0.001 |
| Any FEIA |
40/91 (44%) |
16/29 (55%) |
11/15 (73%) |
17/20 (85%) |
0.003 |
| Aero FEIA |
38/91 (42%) |
16/29 (55%) |
11/15 (73%) |
17/20 (85%) |
0.002 |
| Perennial aero FEIA |
34/91 (37%) |
15/29 (52%) |
11/15 (73%) |
16/20 (80%) |
0.001 |
| Seasonal aero FEIA | 23/91 (25%) | 7/29 (24%) | 4/15 (27%) | 9/20 (45%) | 0.33 |
FEV1 Forced Expiratory Volume at 1 second, FEV1%pred FEV1 percent predicted, FVC forced vital capacity, FVC%pred, FVC percent predicted; FEV0.5, Forced Expiratory Volume at 0.5 second, FEF25-75, Forced expiratory flow at 25% to 75% of FVC; PEF, peak expiratory flow rate; Aero FEIA, aeroallergen fluoroenzyme immunoassay.