Table 1. Means and standard deviations of BMI for each polymorphism, and main effects and post hoc comparisons of SNPs that showed significant main effects and were used in subsequent multiple regression analysis.
SNP | Subsystem | Gene | Maj | Mean | SD | n | Het | Mean | SD | n | Min | Mean | SD | n | F | p | mh | mm | hma | Gene bygenderinteractionF(p) |
rs6651806 | Degradation | MAOB | AA | 20.63 | 2.45 | 381 | AC | 19.95 | 2.16 | 97 | CC | 6.32 | 0.01 | b | 0.40 (0.53) | |||||
rs5905512 | MAOB | AA | 20.76 | 2.62 | 284 | AG | 20.10 | 2.01 | 194 | GG | 9.02 | <0.01 | b | 0.02 (0.89) | ||||||
rs1018079 | Transport | SLC18A1 | AA | 20.29 | 2.26 | 303 | AG | 20.72 | 2.32 | 156 | GG | 22.10 | 4.35 | 18 | 5.92 | <0.01 | 0.07 | <0.01 | 0.02 | 0.34 (0.71) |
rs2270638 | SLC18A1 | AA | 20.33 | 2.47 | 344 | AG | 20.92 | 2.20 | 133 | GG | 5.77 | 0.02 | b | 0.27 (0.60) | ||||||
rs977003 | Receptor | HTR2A | AA | 20.29 | 2.30 | 299 | AC | 20.92 | 2.62 | 151 | CC | 20.40 | 2.19 | 28 | 3.45 | 0.03 | 0.01 | 0.82 | 0.29 | 0.14 (0.87) |
rs2224721 | HTR2A | CC | 20.12 | 2.12 | 216 | AC | 20.79 | 2.61 | 209 | AA | 20.87 | 2.51 | 53 | 4.85 | 0.01 | <0.01 | 0.04 | 0.82 | 0.13 (0.88) | |
rs2192371 | HTR2C | AA | 20.61 | 2.42 | 242 | AG | 19.79 | 1.80 | 124 | GG | 21.03 | 2.78 | 112 | 8.62 | <0.01 | <0.01 | 0.12 | <0.01 | 0.95 (0.33) | |
rs6644065 | HTR2C | AA | 20.45 | 2.26 | 373 | AG | 20.05 | 2.81 | 68 | GG | 21.74 | 2.77 | 37 | 6.30 | <0.01 | 0.21 | <0.01 | <0.01 | 6.06 (0.01) | |
rs4911871 | HTR2C | AA | 20.39 | 2.23 | 350 | AG | 20.17 | 2.74 | 76 | GG | 21.68 | 2.76 | 51 | 7.44 | <0.01 | 0.47 | <0.01 | <0.01 | 1.09 (0.30) | |
rs11214769 | HTR3B | AA | 20.31 | 2.22 | 335 | AG | 20.88 | 2.85 | 124 | GG | 21.21 | 2.20 | 19 | 3.46 | 0.03 | 0.02 | 0.11 | 0.58 | 1.65 (0.19) | |
rs13166761 | HTR4 | GG | 20.38 | 2.23 | 244 | AG | 20.79 | 2.64 | 202 | AA | 19.48 | 1.81 | 32 | 4.74 | 0.01 | 0.07 | 0.05 | <0.01 | 0.54 (0.59) | |
rs7904569 | HTR7 | AA | 20.50 | 2.38 | 206 | AG | 20.69 | 2.53 | 215 | GG | 19.72 | 1.85 | 57 | 3.64 | 0.03 | 0.43 | 0.03 | 0.01 | 1.34 (0.26) |
Note: Empty cells mean no such genotypes were found in our sample. Maj: Major allele; Het: Heterozygote; Min: Minor allele.
Results (p values) of post hoc comparisons. mh = Maj versus Het, mm = Maj versus Min, hm = Het versus Min.
Post hoc comparison was not run because there were only 2 groups for this locus.