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. 2013 Feb 22;8(1):100. doi: 10.1186/1556-276X-8-100

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Copyright ©2013 Li et al; licensee Springer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The mitochondrial functions of N9 cells affected by SWNHs, especially in pre-treated with LPS. Intact cellular basal OCR of N9 cells pre-treated with or without LPS induced by SWNHs measured by Seahorse XF24 analyzer. The OCR of N9 cells pre-treated with LPS (B) was more significant than N9 cells (A). Followed with the increasing concentrations of SWNHs, the OCR of N9 cells decreased significantly in a dose-dependent manner, especially in pre-treated with LPS (B) (P < 0.01). Steady state cellular ATP levels of N9 cells pre-treated with or without LPS induced by SWNHs were measured too. The steady state cellular alkaline phosphatase (APT) level of N9 cells pre-treated with LPS (D) was more significant than N9 cells (C). Followed with the increasing concentrations of SWNHs, the steady state cellular ATP level of N9 cells decreased significantly in a dose-dependent manner, especially in pre-treated with LPS (D) (P < 0.01). All data are represented as mean ± SEM.