Table 2.
Predictors of osteopenia/osteoporosis
| Model 1* | Model 2^ | |||||
|---|---|---|---|---|---|---|
| AOR | CI 95% | p | AOR | CI 95% | p | |
| sex (male) | 1.11 | 0.24-5.17 | .9 | 0.90 | 0.21-3.82 | .9 |
| age (for each additional year) | 1.03 | 0.97-1.10 | .3 | 1.01 | 0.95-1.07 | .7 |
| BMI (for each additional point) | 1.00 | 0.99-1.00 | .9 | 1.00 | 0.99-1.00 | .8 |
| hepatitis co-infection | 1.39 | 0.15-12.7 | .8 | 1.84 | 0.25-13.4 | .5 |
| CD4+ nadir (for 50 cells or more) | 1.08 | 0.88-1.32 | .4 | 1.04 | 0.87-1.24 | .7 |
| time on HAART (for each additional year) | 0.92 | 0.80-1.05 | .2 | 0.93 | 0.81-1.07 | .3 |
| HLA-DR + CD4+ (for each additional %) | 1.08 | 1.01-1.15 | .02 | |||
| CD28 + CD4+ (for each additional %) | 1.06 | 1.0-1.13 | .04 | |||
| HLA-DR + CD8+ (for each additional %) | 1.06 | 1.01-1.11 | .01 | |||
| CD127 + CD8+ (for each additional %) | 0.94 | 0.83-1.06 | .3 | |||
*Model 1: a multivariate logistic regression was performed to explore the association between CD4+ activation and senescence with low BMD, adjusting for demographic and HIV-related parameters. ^Model 2: a multivariate logistic regression was performed to explore the association between activated and central memory CD8+ T cells with low BMD after correction for demographic and HIV-related parameters.