Table 2.
ACS Patient characteristics
| Characteristic | Distribution total cohort | Distribution experienced endpoint | Distribution no end-point | p |
|---|---|---|---|---|
|
Sample size |
407 |
74 |
333 |
|
|
Age |
65 (11.1) |
67.8 (11.8) |
64.5 (10.9) |
0.02 |
|
Men |
76.9% |
78.1% |
76.6% |
0.79 |
|
Diabetes Mellitus |
17.2% |
17.8% |
17.1% |
0.88 |
|
Hypertonia |
43.5% |
52.1% |
41.6% |
0.10 |
|
Current Smoking |
24.8% |
23.3% |
25.1% |
0.74 |
|
Mean time to sample (hours) |
38.4 (32.2) |
42.7 (13.7) |
38.2 (6.9) |
0.28 |
|
Diagnosis |
|
|
|
0.04 |
| STEMI |
42.5% |
53.4% |
40.1% |
0.79 |
| NSTEMI |
35.9% |
35.6% |
35.9% |
|
| Non-MI |
21.6% |
11.0% |
24.0% |
|
| Unstable angina |
63,6% |
85.7% |
62,5% |
|
| Stable angina |
21,6% |
0% |
26.2% |
|
| Chest pain |
14,8% |
14.3% |
11.2% |
|
|
Troponin T (ng/l) |
2.55 (3.76) |
5.14 (5.25) |
1.98 (3.08) |
<0.0000001 |
|
Concurrent therapy |
||||
| Aspirin |
35.1% |
34.2% |
35.3% |
0.79 |
| Beta-adrenergic antagonists |
32.4% |
56.2% |
29.9% |
0.05 |
| Ca2+-channel antagonists |
17.7% |
19.2% |
17.4% |
0.61 |
| Statins |
31.7% |
35.6% |
30.8% |
0.60 |
| ACE inhibitors |
17.7% |
26.0% |
15.9% |
0.08 |
|
Death within 3 months (%) |
1.2% |
6.8% |
0% |
0.000001 |
|
LVEF |
|
|
|
<0.0000001 |
| >50% |
62.8% |
5.6% |
78.7% |
|
| 40-49% |
17.4% |
5.6% |
21.3% |
|
| 30-39% |
14.5% |
67.6% |
0% |
|
| <30% |
4.4% |
21.1% |
0% |
|
|
miRNA (ln 2-∆Ct) |
||||
| miR-1 |
−2.69 (0.99) |
−2.58 (1.08) |
−2.71 (0.97) |
0.32 |
| miR-208b |
−4.59 (2.22) |
−3.70 (2.38) |
−4.78 (2.14) |
0.0001 |
| miR-499-5p | −4.77 (1.80) | −4.03 (2.04) | −4.93 (1.71) | 0.00009 |
Continuous variables are presented as sample mean and standard deviation. P-values reflect comparisons between “Experienced endpoint” and “No endpoint” and are derived from Student’s t-tests for continuous variables and from Pearson’s chi-squared tests for frequency distributions. P-values below the threshold for statistical significance are bolded. STEMI, ST-elevation myocardial infarction; NSTEMI, non ST-elevation myocardial infarction; MI, myocardial infarction; LVEF, left ventricular ejection fraction.