Table 4. Baseline characteristics of individuals dichotomized by whether they had above or below the mean value (271.5 ng/mL) of MMP-9 in the cohort random sample (n = 580).
| Characteristics | MMP-9≤271.5 ng/mL (n = 342) | MMP-9>271.5 ng/mL (n = 226) | p-value for difference |
| Mean (SD) | Mean (SD) | ||
| Age (yr) | 58.7 (5.3) | 58.5 (5.4) | 0.40 |
| BMI (kg/m2) | 28.8 (5.3) | 27.8 (4.9) | 0.93 |
| Physical activity | 2.5 (0.7) | 2.4 (0.8) | 0.30 |
| SBP (mmHg) | 124.9 (20.4) | 121.7 (16.5) | 0.15 |
| DBP (mmHg) | 73.8 (9.9) | 72.4 (9.6) | 0.21 |
| C-reactive protein, mg/L | 4.1 (5.6) | 6.4 (12.1) | 0.005 |
| NT-proBNP, pg/mL | 128.9 (642.7) | 80.5 (93.7) | 0.86 |
| MMP-1 (ng/mL) | 7.1 (4.7) | 7.9 (5.4) | 0.07 |
| MMP-2 (ng/mL) | 175.2 (31.3) | 166.4 (26.4) | 0.02 |
| TIMP-1 (ng/mL) | 155.1 (43.4) | 168.4 (33.2) | 0.0003 |
| TIMP-2 (ng/mL) | 83.9 (16.4) | 81.6 (12.2) | 0.81 |
| CICP (ng/mL) | 3.8 (4.2) | 3.3 (1.0) | 0.16 |
| % | % | % | |
| Female | 51.6 | 37.6 | 0.02 |
| African-American | 52.0 | 28.4 | <0.0001 |
| Current smoker | 15.0 | 32.5 | 0.0001 |
| Diabetes mellitus | 18.0 | 13.9 | 0.85 |
| Prevalent HF | 0.3 | 0.5 | 0.40 |
| Prevalent CHD | 5.9 | 5.7 | 0.62 |
| Hypertension medication | 36.0 | 32.0 | 0.24 |
| Left ventricular hypertrophy | 2.6 | 1.0 | 0.49 |
| High school degree | 69.6 | 73.2 | 0.33 |
*
Models to determine p-value are adjusted for age, race, sex, education and the sampling fraction (weights). BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; NT-proBNP = N-terminal pro-B-type natriuretic peptide; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; CICP = C-terminal propeptide of collagen; HF = heart failure; CHD = coronary heart disease.