Table 1.
Effects of thiolated chitosan modification on size, encapsulation efficiency, and zeta potential
| Group | Polymer | Size (nm) | PDI | Zeta potential (mV) | Drug content (%) | EE (%) | Thiolated chitosan modification |
|---|---|---|---|---|---|---|---|
| CNP |
PCL |
203.56 ± 4.35 |
0.335 |
−19.63 ± 4.10 |
8.69 |
86.55 |
5% |
| UNP |
PLA-PCL-TPGS |
198.46 ± 2.49 |
0.246 |
−18.29 ± 3.25 |
9.89 |
98.79 |
None |
| TNP |
PLA-PCL-TPGS |
206.15 ± 3.66 |
0.286 |
24.66 ± 4.19 |
9.79 |
97.56 |
5% |
| DNP | PLA-PCL-TPGS | 219.33 ± 4.25 | 0.317 | 26.18 ± 5.02 | 9.88 | 98.55 | 20% |
PDI polydispersity index; EE drug entrapment efficiency; n = 3.