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. 2013 Feb 23;14:122. doi: 10.1186/1471-2164-14-122

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Copyright ©2013 Parveen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human enhancer regions can access their target promoters from a distance of ~2 MB. Evolutionary conserved syntenic association between a CNE-enhancer (hs191) and human NR2F1 and harmony in their expression pattern domains in mice infers the functional association among them. The distance between the transcription start site of human NR2F1 and concerned cis-acting site is ~2 MB. Genes are color-coded. Direction of arrow depicts the direction of gene transcription. Light green vertical line depicts the position of CNE-enhancer. Horizontal black line depicts scale.