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3D loading plots. A: Central nervous system specific human enhancers exhibit three distinctive and internally compact clusters exposing the interactive pattern of TFBSs. B: The control data set of human non-conserved and non-coding elements do not present any vivid cluster structure for the fourteen TFBSs that formed internally closely packed clusters in CNS specific enhancers (A), thus elucidating the significance of clusters in panel A. TFBSs are color coded.
