Table 1.
The association of the human CNE-enhancers with their target gene bodies by comparative syntenic analyses and through comparison of the reporter expression induced by CNE-enhancers with the reported endogenous expression patterns of the neighboring genes
|
No. of enhancers |
No. of target genes |
Technique used |
Minimal evidence for association |
||
|---|---|---|---|---|---|
| Paralogy mapping (duplication) | Orthology mapping (synteny) | Only synteny | Synteny along with expression (MGI in-situ) | ||
| 39 |
1 |
√ |
√ |
√ |
¯ |
| 2 |
2 |
√ |
√ |
¯ |
√ |
| 1 |
1 |
√ |
√ |
¯ |
√ |
| 1 |
1 |
√ |
√ |
√ |
* |
| 41 |
2 |
¯ |
√ |
¯ |
√ |
| 7 |
3 |
¯ |
√ |
¯ |
√ |
| 44 |
1 |
¯ |
√ |
√ |
¯ |
| 56 |
1 |
¯ |
√ |
¯ |
√ |
| 1 | 1 | ¯ | √ | √ | * |
This table provides the following information about human CNE-enhancers.
(i) The number of target genes associated with each CNE-enhancer analyzed.
(ii) Whether they are duplicated or not.
(iii) Their association with target gene is supported by either syntenic analysis or by endogenous expression analysis or by both.
* Expression pattern is not known.
MGI: Mouse Genome Informatics.
CNE: Conserved non-coding element.