Table 2.
Prediction results of PLB-SAVE, SiteHound, and MPK2 using the APO dataset (388 proteins).
| APO dataset | PLB-SAVE (373 proteins) | SiteHound (373 proteins) |
|---|---|---|
| Sensitivity | 0.527 | 0.379 |
| Specificity | 0.968 | 0.955 |
| Accuracy | 0.934 | 0.912 |
| PPV | 0.583 | 0.399 |
| MCC | 0.509 | 0.332 |
| (a) | ||
| APO dataset | PLB-SAVE (342 proteins) | MPK2 (342 proteins) |
| Sensitivity | 0.534 | 0.719 |
| Specificity | 0.965 | 0.918 |
| Accuracy | 0.929 | 0.899 |
| PPV | 0.585 | 0.436 |
| MCC | 0.511 | 0.496 |
| (b) | ||
Calculations were performed only on proteins whose binding regions had been successfully predicted by SiteHound and MPK2. Numbers in bold indicate which software gave the better performance for each parameter. (a) PLB-SAVE compared with SiteHound using 373 proteins. (b) PLB-SAVE compared with MPK2 with using 342 proteins.