Table 5.

Univariable and multivariable Cox regression analysis for overall survival

	Univariable		Multivariable
	p-value	HR (95% CI)	p-value	HR (95% CI)
pG	0.053		0.293
1		0.738 (0.232 - 3.267)		.718 (0.220 – 3.220)
2		1.508 (0.545 – 6.251)		1.191 (0.418 – 5.004)
3		2.042 (1.132 – 3.922)		1.658 (0.885 – 3.312)
TNM stage	0.007	2.986 (1.394 – 5.828)	0.015	2.715 (1.234 – 5.499)
ECLNI	0.016	1.974 (1.141 – 3.361)	0.032	1.870 (1.057 – 3.268)
PNI	0.071	1.986 (0.947 – 4.879)	0.222	1.680 (0.750 – 4.521)
≥ 6 genes or/and TGF-β1	0.067	1.734 (0.962 – 3.132)	0.047	1.366 (1.004 – 1.861)

HR (95% CI) hazard ration with 95% confidence interval, pG tumor differentiation, pT tumor stage, ECLNI extracapsular lymph node involvement, PNI perineural invasion.