Table 3.
MACC1 expression and outcomes of post-cryoablation therapy
| |
MACC1 mRNA expression |
P |
MACC1 protein localization |
P |
||
|---|---|---|---|---|---|---|
| High (n = 60) | Low (n = 60) | Cytoplasmic (n = 48) | Nuclear (n = 39) | |||
| TTP |
4.0 |
8.5 |
< 0.001 |
5.0 |
4.0 |
<0.001 |
| 3.0-5.0(M) |
6.3-10.7 (M) |
|
4.2-5.8 (M) |
3.6-4.4 (M) |
|
|
| OS |
9.0 |
12.0 |
0.019 |
11.0 |
8.0 |
0.001 |
| 7.7-10.3 (M) |
7.8-16.2 (M) |
|
8.1-13.9(M) |
6.7-9.2(M) |
|
|
| Overall response rate (CR + PR) |
5(8.3%) |
15(25.0%) |
0.027 |
8(16.7%) |
5(12.8%) |
0.843 |
| Disease control rate (CR + PR + SD) | 31(51.7%) | 44(73.3%) | 0.027 | 33(68.8%) | 17(43.6%) | 0.0321 |
Abbreviations: Overall response rate: includes complete and partial response. Disease control rate: includes complete, partial response and stable disease. M: months.