Figure 4.

Effect of SPC-P with or without SDS on infectivity. Kaplan-Meier survival curves were generated to compare SPC-P treatment conditions with 10-fold serial dilutions of RML scrapie in tga20 mice. A) Treatment with SPC-P_L or SPC-P_H alone had minimal effect on infectivity with 0% survival. B) Combining SPC-P and SDS resulted in 2–3 log₁₀ reductions in infectivity depending on treatment condition. Greater reductions and higher survival percentages were observed with the SPC-P_L + SDS groups in a time-dependent manner. Exposure to SDS alone resulted in an approximate 2 log₁₀ reduction in infectivity (combined data from 30 min., 90 min., and 180 min. exposure groups). Abbreviations: SPC-P_L or _H, low or high concentration sodium percarbonate-based product; SDS, sodium dodecyl sulfate.