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Acute pain in mice induced by Cd. (A) Changes in number of pain-related behaviors (a; licking and biting, b; flicking) of wild-type and TRPA1(−/−) mice after intraplantarly injection of Cd (2 nmol/paw). (B) Summarized number of behaviors during 5 min after Cd injection and HEPES-buffered solution, as a vehicle. Symbols with vertical lines show mean ± SEM. (wild-type; n=7, TRPA1(−/−); n=8) *,P <0.05.
