Table 3.

Identified pathologic stressors that induce mtROS in endothelial cells (ECs)

Cell type	Treatment	Dose	Time	PMID
Bovine aortic ECs	Oxidized LDL	200 μg/ml	30 min	15805232
Bovine aortic ECs	Electrophilic lipids	4 μM	4 h	16387790
Human umbilical vein ECs	LysoPC	5 μmol/L	60 min	16651638
Porcine aortic ECs	Glycated LDL	100 μg/ml	2 h	20036735
Bovine aortic ECs	Glucose	30 mM	2 h	10783895
Human aorta ECs	Glucose	25 mM	7 d	12600878
bEnd3 microvascular ECs	Glucose	40 mM	7 d	21808008
Human umbilical vein ECs	Low Glucose	≤ 80 mg/dL	5 min	22207730
Bovine aortic ECs	Angiotensin II	200 nmol/L	4 h	18096818
Human aortic ECs	Angiotensin II	200 nmol/L	4 h	20448215
Human aortic ECs	Homocysteine	150 μM	24 h	21672628
Human umbilical vein ECs	Hypoxia	14 mmHg	30 min	11950692
Human umbilical vein ECs	Hypoxia	0 mmHg	24 h	12165534
Porcine aortic ECs	Hypoxia	0 mmHg	1 h	12690038
Murine pulmonary ECs	Thrombin	1 mU/mL	100 s	17724077
Human umbilical vein ECs	PAR1-AP	50 μmol/L	1 h	18983479
Human umbilical vein ECs	TNF-α	1 ng/mL	1 h	11415943
Murine pulmonary ECs	TNF-α	1 ng/mL	10 min	21519143
Bovine aortic ECs	Leptin	10 ng/mL	45 min	11342529
Human coronary artery ECs	Resistin	40/80 ng/mL	24 h	20435848
Human umbilical vein ECs	VEGF	50 ng/mL	5 min	21653897

PMID: PubMed ID.