Table 5.
Responsiveness from baseline to week 54
| |
Group: Patients with a > = 5 letter improvement on the ETDRS in their study eye between baseline and week 54 |
||||||
|---|---|---|---|---|---|---|---|
| |
VFQ-25 Change Score |
|
|
Guyatt’s Responsiveness |
|||
| VFQ-25 Domain | n | Mean | P value from one-sample t-test | Effect Size* | SRM† | n | Statistic‡ |
| 1. General Health |
93 |
3.23 |
.14 |
0.15 |
0.15 |
30 |
0.12 |
| 2. General Vision |
93 |
10.32 |
<.001 |
0.55 |
0.56 |
30 |
0.57 |
| 3. Ocular Pain |
93 |
2.96 |
.16 |
0.13 |
0.15 |
30 |
0.14 |
| 4. Near Activities |
93 |
5.69 |
.011 |
0.23 |
0.27 |
30 |
0.29 |
| 5. Distance Activities |
93 |
3.67 |
.12 |
0.15 |
0.16 |
30 |
0.21 |
| 6. Social Functioning |
93 |
0.54 |
.75 |
0.02 |
0.03 |
30 |
0.02 |
| 7. Mental Health |
93 |
4.64 |
.024 |
0.17 |
0.24 |
30 |
0.21 |
| 8. Role Difficulties |
93 |
11.29 |
<.001 |
0.41 |
0.38 |
30 |
0.49 |
| 9. Dependency |
93 |
2.78 |
.25 |
0.09 |
0.12 |
30 |
0.10 |
| 10. Driving |
56 |
5.73 |
.018 |
0.16 |
0.33 |
17 |
0.25 |
| 11. Colour Vision |
91 |
1.92 |
.35 |
0.09 |
0.10 |
30 |
0.09 |
| 12. Peripheral Vision |
93 |
4.30 |
.070 |
0.17 |
0.19 |
30 |
0.19 |
| VFQ-25 Composite | 93 | 4.90 | <.001 | 0.26 | 0.43 | 30 | 0.39 |
* Effect size: the mean change score divided by the standard deviation of the baseline score.
† Standardized response mean: the mean change score divided by the standard deviation of the change score.
‡ Guyatt's responsiveness statistic: the mean change score divided by the standard deviation of change in subjects who remained stable. Stable groups are defined as an increase or a decrease of up to 1 letter.