Figure 11.

Autometallographic evaluation of tissue distribution of QD 28 days post-exposure. Silver enhancement staining of QD in lung tissue of rats 28 days after intratracheal instillation 12.5 μg of QD-COOH (B-D) or PBS (control) (A): a high magnification micrograph of QD-COOH showing AM clustered around vessels walls (B), a low magnification micrograph of a vessel with QD-COOH in and surrounding areas that may be perivascular lymphatic vessels (C), and several serial sections from the boxed area of Panel C imaged and stacked together at high magnification to illustrate accumulation of QD in and around a possible lymphatic vessel (D).