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. 2013 Mar 4;10:5. doi: 10.1186/1743-8977-10-5

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Copyright ©2013 Roberts et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Confocal evaluation of AM uptake of QD in vivo. Confocal micrographs (63x-zoomed or 100x objective) of AM from the BAL of rats 1 (A-C) and 28 (D-F) days after intratracheal instillation with 12.5 μg QD-NH₂ or QD-COOH (red/yellow), or PBS (control): (A) control – 1 day post-exposure, (B) QD-NH₂ - 1 day post-exposure, (C) QD-COOH – 1 day post-exposure, (D) control – 28 days post-exposure, (E) QD-NH₂ - 28 days post-exposure, and (F) QD-COOH – 28 days post-exposure. AM are green and QD are yellow/red. PMN uptake of QD is shown in the smaller inset micrograph in panel C (arrows).