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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Chem Rev. 2012 Dec 3;113(3):2182–2204. doi: 10.1021/cr300169a

Figure 11. The Active Sites of the Two Hydroxybenzoyl-CoA Thioesterases.

Figure 11

(A) 4HBT-I (PDB#1LO9) shown in orange. The structure includes inhibitor 4-hydroxyphenacyl-CoA shown in black. (B) 4HBT-II (PDB#1Q4S) shown in yellow. The structure includes the products 4-hydroxybenzoate and coenzyme A shown in black. For both (A) and (B) only the N-acetylcysteamine portion of CoA has been drawn and side chains of some residues, particularly of residues involved in loop β1–αHD, are not shown for the purpose of figure clarity. Below each structural image is a two-dimensional representation of selected residues of each active site.