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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Chem Rev. 2012 Dec 3;113(3):2182–2204. doi: 10.1021/cr300169a

Figure 14. Further Hot Dog Thioesterase Active Site Arrangements.

Figure 14

(A) The active site of S. cattleya FlK (PDB#3KVU), an example of an SHD TE, in plum, including acetyl-CoA shown in black. Only the N-acetylcysteamine portion of CoA has been drawn for the purpose of figure clarity. (B) The active site of M. chernisa DynE7 (PDB#2XEM), another SHD TE, in magenta, including the proposed product trans-3,5,7,9,11,13-pentadecahexaen-2-one (5) shown in black. (C) The active site of M. tuberculosis FcoT (PDB#2PFC), another SHD TE, in purple, including the product trans-dodecenoate shown in black.