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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Chem Rev. 2012 Dec 3;113(3):2182–2204. doi: 10.1021/cr300169a

Figure 9. Comparison of Active Site Tunnels Between FabA and FabZ.

Figure 9

The enzyme backbones are drawn with solid ribbons, the catalytic histidines are shown with scaled balls and sticks. (A) Fab A (PDB#1MKA), the dehydratase–isomerase, in green with the active site volume indicated by a faint pink cloud. (B) P. aeruginosa Fab Z (PDB#1U1Z), the standard dehydratase, in orange with the active site volume indicated by a faint blue cloud. Note the shorter binding tunnel in FabA and the slight difference in the angle of the two tunnels (indicated with dashed lines), hypothesized to allow for C-3 cis double bond formation in FabA.