Table 1.
Immunohistochemical labelling (filaggrin, loricrin), histopathology and transepidermal water loss
| Time | 0 h | 1 hpi | 3 hpi | 6 hpi | 24 hpi |
|---|---|---|---|---|---|
| Filaggrin (average MFI/mm) |
189 (34.43-751.01)* |
236.16 (93.57-469.30)* |
160.95 (23.69-370.62)* |
N/A |
11.49 (0–44.59)* |
| Loricrin (average MFI/mm) |
122.06 (83.79-227.59)* |
225.15 (69.60-402.44)* |
171.71 (0.09-305.21)* |
N/A |
55.28 (0–213.95)* |
| Mean PMN cell count per mm2 |
9.13 (0.97-31.91)* |
92.09 (12.57-207.93)* |
1099.83 (410.06-1959.38)* |
N/A |
1174.16 (1098.65-2330.75)* |
| TEWL (g/m2h) | 20.54 (13.62-29.48)* | 598.67 (598–662)* | 585.17 (597.67-637)* | 516.46 (403.83-597.33)* | 396.75 (331.17-481)* |
Mean fluorescence intensity (MFI)/mm epithelium for filaggrin and loricrin and mean polymorphonuclear (PMN) cell counts /mm2 at time 0, 1, 3 and 24 hours post-infestation (hpi). Transepidermal water loss (TEWL) g/m2h at 0,1,3,6 and 24 hpi. *Reference range.