Table 2.
Microarray analysis of the genes that were upregulated in one or both gatifloxacin-resistant mutants, 13124R and NCTRR
|
Gene ID and name |
Function/Similarity |
Microarray (mt/wt) |
||
|---|---|---|---|---|
| NCTR | ATCC 13124 | |||
|
Amino acid biosynthesis |
|
|
|
|
| CPE1520 |
CPF_1772 (ilvE) |
branched-chain amino acid aminotransferase |
1.1 |
2.6 |
| CPE1905 |
CPF_2161 (dapA) |
dihydrodipicolinate synthase |
1.0 |
1.9 |
|
Cell envelope | ||||
| CPE0492 |
CPF_0465 |
capsular polysaccharide biosynthesis protein |
6.5 |
1.9 |
| CPE0495 |
CPF_0468 |
UDP-glucose/GDP-mannose dehydrogenase family |
3.5 |
2.4 |
| CPE2059 |
CPF_2316 |
putative membrane protein |
7.1 |
3.2 |
| CPE2079 |
CPF_2336 |
putative membrane protein |
14.2 |
2.1 |
| CPE0785 |
CPF_0787 |
putative membrane protein |
2.3 |
2.1 |
|
Energy metabolism | ||||
| CPE2186 |
CPF_2451 (atpE) |
ATP synthase epsilon subunit |
3.3 |
2.9 |
| CPE2187 |
CPF_2452 (atpB) |
ATP synthase beta subunit |
3.6 |
2.2 |
| CPE2189 |
CPF_2454 (atpA) |
ATP synthase alpha subunit |
4.2 |
2.4 |
| CPE2190 |
CPF_2455 (atpH) |
ATP synthase delta subunit |
1.9 |
2.1 |
| CPE2191 |
CPF_2456 (atpF) |
ATP synthase B chain |
2.2 |
2.3 |
| CPE2192 |
CPF_2457 (atpL) |
ATP synthase C chain |
3.6 |
2.3 |
|
Fatty acid and phospholipid metabolism | ||||
| CPE1068 |
CPF_1324 (fabH) |
3-oxoacyl-(acyl-carrier-protein) synthase III |
2.2 |
4.7 |
| CPE1069 |
CPF_1325 (fabD) |
malonyl CoA-acyl carrier protein transacylase |
1.1 |
3.6 |
| CPE1071 |
CPF_1327 (fabF) |
3-oxoacyl-(acyl-carrier-protein) synthase II |
1.3 |
3.8 |
| CPE1072 |
CPF_1328 (accB) |
acetyl-CoA carboxylase, biotin carboxyl carrier |
0.9 |
4.0 |
| CPE1073 |
CPF_1329 (fabZ) |
beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ |
1.0 |
4.5 |
| CPE1074 |
CPF_1330 (accC) |
acetyl-CoA carboxylase, biotin carboxylase |
1.7 |
4.9 |
| CPE1075 |
CPF_1331 (accD) |
acetyl-CoA carboxylase, carboxyl transferase, beta subunit |
3.4 |
5.0 |
| CPE1076 |
CPF_1332 (accA) |
acetyl-CoA carboxylase, carboxyl transferase, alpha subunit |
1.9 |
4.6 |
|
Protein synthesis | ||||
| CPE1697 |
CPF_1951 (frr) |
ribosome recycling factor |
1.1 |
2.0 |
| CPE2441 |
CPF_2720 |
ribosomal protein L7AE family |
1.1 |
2.6 |
| CPE2660 |
CPF_2997 (rpmH) |
ribosomal protein L34 |
1.4 |
2.0 |
|
Purine, pyrimidine, nucleotides, and nucleosides | ||||
| CPE1050 |
CPF_1305 (mtnH) |
5-methylthioadenosine/S-adenosylhomocysteine nuclosidase |
3.2 |
2.6 |
| CPE2162 |
CPF_2418 (cpdC) |
2`,3`-cyclic-nucleotide 2`-phosphodiesterase |
3.4 |
1.6 |
|
Transport and binding proteins | ||||
| CPE0977 |
CPF_1235 |
potassium transporter |
7.1 |
2.9 |
|
Unknown functions | ||||
| CPE2601 | CPF_2928 | conserved hypothetical protein | 6.7 | 58.0 |
All of the data are the means of three different experiments.