Table 3.

Microarray analysis of the genes that were downregulated in both gatifloxacin-resistant strains, 13124^R and NCTR^R

Gene ID (name)		Function/Similarity	Microarray (mt/wt)
			NCTR	ATCC 13124
Biosynthesis of cofactors, prosthetic groups, and carriers
CPE1085	CPF_1341 (ispH)	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	−2.4	−2.2
Energy metabolism
CPE0292	CPF_0288	carbohydrate kinase family protein	−3.1	−2.5
CPE1185	CPF_1389 (pfk)	6-phosphofructokinase	−1.7	−2.7
CPE0585	CPF_0565 (fruB)	fructose-1-phosphate kinase	−5.2	−2.3
CPE0692	CPF_0684	transaldolase	−2.8	−2.3
CPE0725	CPF_0721 (nanI) *	exo-alpha-sialidase	−3.5	1.5
CPE0894	CPF_0887 (eutP)	ethanolamine utilization protein, EutP	−1.9	−2.0
CPE2348	CPF_2657 (ptb)	phosphate butyryltransferase	−2.3	−1.6
Purine, pyrimidine, nucleotides, and nucleosides
CPE1398	CPF_1652 (deoD)	purine nucleoside phosphorylase	−1.7	−3.4
Regulatory functions
CPE0586	CPF_0566 (fruR)	transcriptional regulator, DeoR family	−3.6	−2.6
CPE0631	CPF_0612	probable PBP5 synthesis regulator protein	−2	−2.5
CPE1077	CPF_1333	transcriptional regulator, PadR family	−3.1	−3.2
CPE2510	CPF_2833	transcriptional regulator, PadR family	−2.6	−2.7
CPE1305	CPF_1512	probable transcriptional regulator	−2	−1.6
Transport and binding proteins
CPE0600	CPF_0581	amino acid ABC transporter	−4.8	−3.4
CPE1534	CPF_1785	PTS system, sucrose-specific IIBC component	−3.1	−14.3
CPE2345	CPF_2654	putative maltose/maltodextrin ABC transporter	−2.0	−1.8
Unknown functions
CPE2509	CPF_2832	degV family protein	−3.6	−3.3
CPE1171	CPF_1374	mutator mutT protein homolog	−6.4	−2.0
CPE2592	CPF_2917	phnA family protein	−2. 8	−2.0

^* Decrease in the expression of nanI in NCTR^R and increase of its expression in 13124^R was confirmed by qRT-PCR.

All of the data are the means of three different experiments.