Table 1.
Significantly over-represented gene ontology biological processes associated with differentially expressed genes in the colon of mice supplemented with adequate levels of selenium and folate post-weaning (n = 6 per treatment)
| Term | GOid | Gene name | Systematic name | Description | Fold change | P value |
|---|---|---|---|---|---|---|
| Organelle organization |
GO:0006996 |
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| |
|
Stx6 |
NM_021433 |
Mus musculus syntaxin 6 |
−1.6 |
0.003 |
| |
|
Col4a3bp |
NM_023420 |
Mus musculus procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
−1.5 |
0.004 |
| |
|
Pom121 |
NM_148932 |
Mus musculus nuclear pore membrane protein 121 |
−1.7 |
0.004 |
| |
|
Shprh |
AK037266 |
Mus musculus 16 days neonate thymus |
−1.6 |
0.003 |
| Lipid homeostasis |
GO:0055088 |
Col4a3bp |
NM_023420 |
Mus musculus procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
−1.5 |
0.004 |
| |
|
Plscr3 |
NM_023564 |
Mus musculus phospholipid scramblase 3 |
−1.6 |
0.007 |
| Cellular component organization |
GO:0016043 |
Nov |
NM_010930 |
Mus musculus nephroblastoma overexpressed gene |
−1.7 |
0.005 |
| |
|
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| |
|
Stx6 |
NM_021433 |
Mus musculus syntaxin 6 |
−1.6 |
0.003 |
| |
|
Col4a3bp |
NM_023420 |
Mus musculus procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
−1.5 |
0.004 |
| |
|
Pom121 |
NM_148932 |
Mus musculus nuclear pore membrane protein 121 |
−1.7 |
0.004 |
| |
|
Shprh |
AK037266 |
Mus musculus 16 days neonate thymus |
−1.6 |
0.003 |
| Nuclear pore organization |
GO:0006999 |
Pom121 |
NM_148932 |
Mus musculus nuclear pore membrane protein 121 |
−1.7 |
0.004 |
| Cellular process |
GO:0009987 |
Heph |
NM_181273 |
Mus musculus hephaestin, transcript variant 2 |
−1.5 |
0.001 |
| |
|
Mef2a |
NM_001033713 |
Mus musculus myocyte enhancer factor 2A |
−1.6 |
0.001 |
| |
|
Nov |
NM_010930 |
Mus musculus nephroblastoma overexpressed gene |
−1.7 |
0.005 |
| |
|
Rora |
AK087905 |
Mus musculus 2 days pregnant adult female ovary |
−1.8 |
0.001 |
| |
|
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| |
|
Mtmr1 |
NM_016985 |
Mus musculus myotubularin related protein 1 |
−1.6 |
0.008 |
| |
|
Stx6 |
NM_021433 |
Mus musculus syntaxin 6 |
−1.6 |
0.003 |
| |
|
Col4a3bp |
NM_023420 |
Mus musculus procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
−1.5 |
0.004 |
| |
|
Pom121 |
NM_148932 |
Mus musculus nuclear pore membrane protein 121 |
−1.7 |
0.004 |
| |
|
Shprh |
AK037266 |
Mus musculus 16 days neonate thymus |
−1.6 |
0.003 |
| |
|
Podxl2 |
NM_176973 |
Mus musculus podocalyxin-like 2 |
−1.6 |
0.005 |
| DNA packaging |
GO:0006323 |
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| |
|
Shprh |
AK037266 |
Mus musculus 16 days neonate thymus |
−1.6 |
0.003 |
| DNA conformation change |
GO:0071103 |
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| |
|
Shprh |
AK037266 |
Mus musculus 16 days neonate thymus |
−1.6 |
0.003 |
| DNA metabolic process |
GO:0006259 |
Top2a |
NM_011623 |
Mus musculus topoisomerase (DNA) II alpha |
−1.7 |
0.006 |
| Shprh | AK037266 | Mus musculus 16 days neonate thymus | −1.6 | 0.003 |
A positive fold change indicates that supplementation increased the expression of the gene.